Immunohistochemical Expression of c-kit Receptor (CD117) in Two Pigmentary Disorders
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چکیده
منابع مشابه
Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias.
BACKGROUND AND OBJECTIVE The receptor for stem cell factor (CD117) is the gene product of the c-kit proto-ontogene. Together with its ligand, the stem cell factor (SCF), it plays an important role in hematopoiesis. In this study, we review the cellular distribution of CD117 in normal hematopoiesis and in hematopoietic malignancies focusing on the differential expression in subtypes of acute leu...
متن کاملPotential use of imatinib mesylate in ocular melanoma and liposarcoma expressing immunohistochemical c-KIT (CD117).
Potential use of imatinib mesylate in ocular melanoma and liposarcoma expressing immunohistochemical c-KIT (CD117) KIT is a transmembrane tyrosine kinase receptor in which the extracellular portion binds a ligand known as stem-cell factor and the intracellular portion contains the kinase enzymatic domain. KIT is similar in structure to several other receptor tyrosine kinases with oncogenic capa...
متن کاملImmunohistochemical Expression of Epidermal Growth Factor Receptor and c-Kit in Triple Negative Breast Cancer.
OBJECTIVE To determine the frequency of immunohistochemical expression of epidermal growth factor receptor (EGFR) and c-KITin triple negative breast cancer (TNBC). STUDY DESIGN Descriptive, cross-sectional study. PLACE AND DURATION OF STUDY Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January to December 2014. METHODOLOGY Fifty cases of triple negative breast cancer diagno...
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To determine the frequency of c-Kit staining in desmoids and optimize an assay for clinical use, we stained 19 desmoids from various sites at various dilutions with 2 commonly used rabbit polyclonal, anti-c-Kit antibodies (A4502, DAKO, Carpinteria, CA; C-19, Santa Cruz Biotechnology, Santa Cruz, CA), with and without heat-induced epitope retrieval (HIER) in citrate buffer. Approdpriate external...
متن کاملErratum to “Evaluation of the Expression of C-Kit (CD117) in Ependymomas and Oligodendrogliomas”
C-kit is a proto-oncogene located on the long arm of chromosome 4. Its product, CD117, is a specific immunohistochemical (IHQ) marker that is associated with response to a potent tyrosine kinase inhibitor therapy with STI-571 (Gleevec®) in chronic myelogenous leukemia and GISTs. In our study, we aimed to evaluate the expression of CD117 in glial tumors as this finding may guide therapeutic appr...
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ژورنال
عنوان ژورنال: Journal of Clinical & Experimental Dermatology Research
سال: 2013
ISSN: 2155-9554
DOI: 10.4172/2155-9554.1000190